Comic Life 1.3.4 plays nice with iPhoto: "plasq has posted an update to Comic Life today that allows the user-generated comic book creating application to, once again, interact properly with iPhoto. With the update applied, Comic Life will correctly display iPhoto '08 libraries and you might also see improvements in Comic Life's stability...usually a good thing. The 1.3.4 update is free for registered users. If you'd like to purchase Comic Life, you may do so for USD$24.95 by buying online. Comic Life is also available at various retail outlets.
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